____ _ _ _ _
| _ \ ___ | |_ (_) _ __ ___ __| | (_) __ _
| |_) | / _ \ | __| | | | '_ \ / _ \ / _| | | | / _ |
| _ < | __/ | |_ | | | |_) | | __/ | (_| | | | | (_| |
|_| \_\ \___| \__| |_| | .__/ \___| \__,_| |_| \__,_|
|_|
- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b- `b
Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―Β―
Macrosialin
ββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββ
top
Macrosialin (synonym CD68) ist ein OberflΓ€chenprotein aus der Gruppe der LAMP-Proteine und ein ZelladhΓ€sionsmolekΓΌl.
Contents
β’ Eigenschaften
β’ Anwendungen
β’ Weblinks
β’ Einzelnachweise
ββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββ
Eigenschaften
Macrosialin wird von Monozyten und Makrophagen (sowie deren gewebespezifischen residenten GegenstΓΌcken, Histiozyten, Riesenzellen, Kupffer-Zellen und Osteoklasten) gebildet und ist ein Zelltypmarker.cite-ref-chistiakov-1-0[1]cite-ref-pmid19218902-2-0[2]cite-ref-pmid7680921-3-0[3] Weiterhin wird es von Lymphozyten, Fibroblasten und Endothelzellen erzeugt. DarΓΌber hinaus wird es auch von verschiedenen Tumoren zur Ausbildung von Zellkontakten gebildet. Macrosialin ist glykosyliert.
Macrosialin bindet an oxidiertes LDL, Phosphatidylserin und an apoptotische Zellen.cite-ref-chistiakov-1-1[1]
Anwendungen
Eine CD68-ImmunfΓ€rbung wird bei der Diagnose der malignen Histiozytose, beim histiozytΓ€ren Sarkom und bei Morbus Gaucher eingesetzt.cite-ref-leong-4-0[4]cite-ref-pmid19147301-5-0[5]
Weblinks
Einzelnachweise
cite-note-chistiakov-11. β D. A. Chistiakov, M. C. Killingsworth, V. A. Myasoedova, A. N. Orekhov, Y. V. Bobryshev: CD68/macrosialin: not just a histochemical marker. In: Laboratory investigation; a journal of technical methods and pathology. Band 97, Nr. 1, Januar 2017, S. 4β13, doi:10.1038/labinvest.2016.116, PMID 27869795.
cite-note-pmid19218902-22. β Osterne R, Matos-Brito R, Alves AP: Oral Granulocytic Sarcoma : A case report. In: Med Oral Patol Oral Cir Bucal. 14. Jahrgang, Nr. 5, Februar 2009, S. E232β5, PMID 19218902 (englisch, medicinaoral.com (Memento des Originals vom 6. MΓ€rz 2009 im Internet Archive)).
cite-note-pmid7680921-33. β Holness CL, Simmons DL: Molecular cloning of CD68, a human macrophage marker related to lysosomal glycoproteins. In: Blood. 81. Jahrgang, Nr. 6, MΓ€rz 1993, S. 1607β13, PMID 7680921 (englisch).
cite-note-leong-44. β Anthony Leong, Kumarason Cooper, Joel Leong: Manual of Diagnostic Cytology. 2. Auflage. Greenwich Medical Media, Ltd., 2003, ISBN 1-84110-100-1, S. 135β136 (englisch).
cite-note-pmid19147301-55. β Manduch M, Dexter DF, Jalink DW, Vanner SJ, Hurlbut DJ: Undifferentiated pancreatic carcinoma with osteoclast-like giant cells: Report of a case with osteochondroid differentiation. In: Pathol. Res. Pract. 205. Jahrgang, Nr. 5, Januar 2009, S. 353β9, doi:10.1016/j.prp.2008.11.006, PMID 19147301 (englisch).